In this study, the authors evaluated the comparative effects of dietary supplementation of ginger (Zingiber officinale), vitamin E and L-carnitine on certain blood parameters of two strains of broilers in summer. A total of 320 broiler chicks (Hubbard and Cobb) were divided into two groups. The two groups were subdivided into four subgroups with four replicates with 10 chicks per replicate. In each strain subgroup was kept as control while other subgroups were provided with ginger (2%), L-carnitine (500 mg/kg) or vitamin E (250 mg/kg) in the basal diet up to 42 days old. Supplementation of the diet with vitamin E, ginger and L-carnitine significantly decreased mean cholesterol, alanine aminotransferase (ALT), glucose, triglyceride, low density lipoprotein (LDL), and increased high density lipoprotein (HDL) and serum protein concentrations. The results of vitamin E were comparatively better than those of the other two feed additives. The blood biochemical parameters did not vary between the broiler strains. From the findings of the current study, it was concluded that high ambient temperature had a negative effect on broiler hepatic and lipid profiles, and the supplementation of diets with vitamin E, ginger and L-carnitine improved broiler blood biochemical parameters.