Fourteen Holstein calves, two to four days of age, were randomly divided into two groups to determine the effect of abomasal curd suppression on selected blood profiles. Calves received a milk replacer in which casein coagulation either was normal (CM), or was prevented by the precipitation of Ca++ with an oxalic acid – sodium hydroxide buffer (NCM). Jugular blood samples were taken before the morning feeding (0 h), as well as at 1, 2, 4 and 6 h postfeeding. Fasting (0 h) plasma free essential amino acid (EAA) concentration tended to be higher for the CM treatment than for the NCM treatment, while the contrary was observed for postprandial values up to 6 h post-feeding. Plasma EAA concentration increased significantly during the first hour post-feeding for the NCM treatment, whereas values remained fairly constant for the CM treatment. Plasma triglyceride concentration was significantly higher for the CM treatment at 0, 4 and 6 h post-feeding, while it was higher for the NCM treatment at 1 h post-feeding. The fasting plasma glucose concentration was similar for both treatments. Plasma glucose was significantly higher for the CM treatment at 2 h post-feeding, but the contrary was observed thereafter. For the CM treatment, the plasma glucose profile almost mirrored the triglyceride profile. It was concluded that profiles of plasma free EAA and triglycerides may be reliable indicators of in vivo curd-forming ability of a given milk replacer, and that abomasal curd suppression may have a detrimental effect on amino acid and caloric homeostasis.