This study provides the first account of genetic relationships between three indigenous cattle breeds from Mozambique. Forty-two blood group factors and six blood proteins revealed genetic variation of 84% (Angone), (Bovine de Tete) and 90% (Landim) at the loci studied. Average heterozygosity values ranged from 33% for Angone and Bovine de Tete to 35% for the Landim. The genetic distance was greatest between the Landim and both the Bovine de Tete and the Angone breeds, whereas the smallest genetic distance was observed between the Bovine de Tete and the Angone. These results show the intermediate relationship of Bovine de Tete with the Angone and Landim breeds and show that the Bovine de Tete is an admixture of taurine and indicus genes.